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Peganum harmala extract
- Development stage
- Phase 2
- Lead developer
- Hashemite University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Inhalation, Topical
01
Overview
Peganum harmala extract is a botanical extract derived from the seeds, roots, or leaves of the *Peganum harmala* plant (commonly known as Syrian rue or Harmal). It contains active beta-carboline alkaloids, primarily harmine, harmaline, and tetrahydroharmine, which act as reversible inhibitors of monoamine oxidase A (MAO-A). The extract has been investigated for various pharmacological properties, including antimicrobial, anti-inflammatory, antioxidant, and psychoactive effects. In recent research, chitosan nanoparticles loaded with *Peganum harmala* extract have been studied for their antibacterial and antibiofilm activity against multidrug-resistant *Pseudomonas aeruginosa* isolates from cystic fibrosis patients, demonstrating potential in downregulating quorum-sensing genes and controlling chronic lung infections.
- Other names
- Harmal extractPeganum harmala L. extractPeganum harmala seed extractSyrian rue extract
02
Targets
AcetylcholinesteraseButyrylcholinesteraseMAOA (Monoamine oxidase A)
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