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peginterferon alfa-2a + ribavirin + betaine
- Development stage
- Phase 1
- Lead developer
- Roche
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous, Oral
01
Overview
A combination therapy consisting of peginterferon alfa-2a, ribavirin, and betaine that was investigated for the treatment of chronic hepatitis C virus (HCV) infection, particularly for non-responders or relapsers to previous therapy. Peginterferon alfa-2a is a pegylated form of interferon alfa-2a that has a longer half-life allowing for once-weekly dosing. Ribavirin is an antiviral medication that enhances the efficacy of interferon therapy. Betaine was added to this standard combination as an experimental approach.
- Other names
- Betaine with PegIFN/RBVBetaine + Peginterferon alpha-2a + Ribavirin
02
Targets
BHMT (Betaine-homocysteine S-methyltransferase)NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)IFNAR (Immune system modulation via type I interferon receptor)
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