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peginterferon alfacon-2 + tenofovir alafenamide
- Development stage
- Unknown
- Lead developer
- Kawin Technology
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Subcutaneous, Oral
01
Overview
Combination of **peginterferon alfacon-2** (a pegylated form of recombinant interferon alpha with immunomodulatory and antiviral effects) and **tenofovir alafenamide** (a nucleotide reverse transcriptase inhibitor prodrug) used primarily for the treatment of **chronic hepatitis B (CHB)**. Peginterferon alfacon-2 stimulates the immune response against hepatitis B virus, while tenofovir alafenamide is converted in hepatocytes to the active metabolite tenofovir diphosphate, which inhibits hepatitis B virus polymerase (reverse transcriptase), terminating viral DNA synthesis. This combination aims to achieve higher functional cure rates than monotherapy, offering both direct antiviral effects and immune modulation. Studied in both adults and pediatric populations, with evidence of functional cure and safety profile documented for both groups[1][3][4].
- Other names
- pegifn-alfacon-2 + tafpegylated interferon alfa + tenofovir alafenamidepeginterferon alfa + tenofovir alafenamide
02
Targets
IFNAR (Immune system modulation via type I interferon receptor)HBV Pol (Hepatitis B virus polymerase)
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