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peguricase
- Development stage
- Phase 1
- Lead developer
- Shanghai Institute of Biological Products
- Modality
- Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes, Metabolic Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Injection
01
Overview
Peguricase is a PEGylated recombinant uricase (urate oxidase) enzyme developed by the Shanghai Institute of Biological Products for the treatment of gout, particularly in patients whose condition remains uncontrolled by conventional uric acid-lowering therapies. As a biologic therapy, it functions by converting uric acid into allantoin, a highly soluble metabolite that is easily excreted by the kidneys. The PEGylation of the enzyme is designed to extend its circulating half-life and potentially reduce immunogenicity compared to non-modified urate oxidase. It is currently being evaluated in Phase 1 clinical trials both as a monotherapy and in combination with methotrexate, where the latter is intended to further mitigate the formation of anti-drug antibodies and enhance treatment response rates in refractory gout cases.
- Other names
- PEGylated uricasePEGylated urate oxidaserecombinant uricase
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