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pegylated G-CSF
- Development stage
- Unknown
- Lead developer
- Amgen
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
Pegylated granulocyte colony-stimulating factor (G-CSF) is a long-acting biologic agent used as supportive care to stimulate the production of neutrophils and reduce the risk of febrile neutropenia in patients undergoing myelosuppressive chemotherapy. It is a pegylated form of recombinant human G-CSF (filgrastim), created by the covalent attachment of a polyethylene glycol (PEG) polymer. This modification increases the hydrodynamic size of the protein, thereby reducing renal clearance and significantly extending its plasma half-life compared to non-pegylated G-CSF. This allows for a single subcutaneous dose per chemotherapy cycle rather than daily injections. The drug acts as an agonist at the G-CSF receptor (CSF3R) on hematopoietic progenitor cells in the bone marrow, promoting their proliferation, differentiation, and activation into mature, functional neutrophils. Common examples include pegfilgrastim and lipegfilgrastim.
- Brand names
- NeulastaLonquexFulphilaUdenycaZiextenzoNyvepriaNeulapeg
- Other names
- pegylated granulocyte colony-stimulating factorpeg-G-CSFpegfilgrastimlipegfilgrastimempegfilgrastimmecapegfilgrastim
02
Targets
CSF3R (Granulocyte colony-stimulating factor receptor)
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