PEGylated GIP (1-30) analogue

PEGylated GIP (1-30) analogue (specifically [D-Ala(2)]GIP(1-30)-PEG) is a long-acting, dipeptidyl peptidase-4 (DPP-4)-resistant analogue of the short-form glucose-dependent insulinotropic polypeptide (GIP(1-30)). GIP(1-30) is a peptide hormone produced by pancreatic alpha cells that promotes insulin secretion in a paracrine manner. The analogue is modified at the second position (alanine to D-alanine) to confer DPP-4 resistance and is conjugated to a 40 kDa polyethylene glycol (PEG) moiety at the C-terminus to extend its half-life to approximately 48 hours. It acts as a GIP receptor agonist, improving islet function and morphology, preserving beta-cell area by inhibiting apoptosis, and suppressing alpha-cell expansion. It has been investigated in preclinical models for the treatment of diabetes and hyperglycemia without inducing obesity.

Other names

[D-Ala(2)]GIP(1-30)-PEG[D-Ala2]GIP(1-30)-PEGPEGylated GIP(1-30)PEGylated [D-Ala(2)]GIP(1-30)PEGylated [D-Ala2]GIP(1-30)long-acting GIP (1-30) analogue