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Peitu Zhiqi Decoction is a traditional herbal formulation developed by the Hohhot Mongolian Medicine Hospital of Traditional Chinese Medicine for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). Based on traditional therapeutic principles, the decoction aims to tonify the spleen and resolve dampness (a concept often referred to as strengthening the earth or Peitu) to alleviate gastrointestinal symptoms. Clinical investigation (ChiCTR2400083726) focuses on its efficacy in reducing diarrhea and its regulatory effect on 5-hydroxytryptamine (5-HT, or serotonin) levels. Serotonin is a key neurotransmitter involved in regulating intestinal motility and visceral hypersensitivity, and its modulation is a primary target for managing IBS-D symptoms.
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