Peking Univ. FGFR4 compound 10v

Peking Univ. FGFR4 compound 10v: sourced facts only. name: "Representative compound 10v exhibited potent FGFR4 inhibition (IC50 = 1.2 nM) and a high selectivity among the tested kinases." [PMID:41187564]; target: "Representative compound 10v exhibited potent FGFR4 inhibition (IC50 = 1.2 nM) and a high selectivity among the tested kinases." [PMID:41187564]; developer: "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, 518055, China." [PMID:41187564]; modality: "Herein, we report a novel series of 7-azaindole-based compounds as potential type-II covalent inhibitors against FGFR4 kinase." [PMID:41187564]; stage: "Moreover, compound 10v exhibited significant in vivo antitumor activity in a HuH-7 mouse xenograft model." [PMID:41187564]