Peking Univ. GPX4 compound 8e

Peking Univ. GPX4 compound 8e: sourced facts only. name: "Hence, 8e was discovered as a potent and highly efficacious GPX4 degrader based upon the inhibitor RSL3." [PMID:36603510]; target: "Hence, 8e was discovered as a potent and highly efficacious GPX4 degrader based upon the inhibitor RSL3." [PMID:36603510]; developer: "Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, Beijing, China. Electronic address: [email protected]." [PMID:36603510]; modality: "we designed and synthesized a series of GPX4 degraders using PROTAC technology in terms of its excellent characteristics such as high efficiency and selectivity and the capacity of overcoming resistance." [PMID:36603510]; stage: "Our data also suggested that 8e and RSL3 could potently induce ferroptosis of HT1080 cells via GPX4 inhibition and degradation." [PMID:36603510]