Peking Univ. GPX4 compound R17

Peking Univ. GPX4 compound R17: sourced facts only. name: "Compound R17 with carbon chain linker and lenalidomide E3 ligand was selected as the most potent GPX4 degrader for degrading GPX4 protein in nanomolar level either in wild tumor cells or in drug-resistant tumor cells." [PMID:37098297]; target: "Compound R17 with carbon chain linker and lenalidomide E3 ligand was selected as the most potent GPX4 degrader for degrading GPX4 protein in nanomolar level either in wild tumor cells or in drug-resistant tumor cells." [PMID:37098297]; developer: "State Key Laboratory of Natural and Biomimetic Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, Beijing, China." [PMID:37098297]; modality: "In this work, we designed, synthesized and evaluated a series of RSL3-based GPX4 degraders using PROTAC strategy." [PMID:37098297]