Drug intelligence / Profile preview

pelubiprofen + eperisone

Development stage
Unknown
Lead developer
Daewon Pharm
Modality
Small Molecules
Administration
Oral
01

Overview

Pelubiprofen + eperisone is a fixed-dose oral combination developed by Daewon Pharmaceutical for the treatment of musculoskeletal pain and muscle spasms, particularly in conditions such as back pain. Pelubiprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the profen class that acts primarily as a cyclooxygenase inhibitor, reducing inflammation and pain. Eperisone is a centrally acting muscle relaxant that works by blocking voltage-gated calcium and sodium channels in the spinal cord, leading to reduced nerve conduction and decreased muscle spindle sensitivity; it also has vasodilatory effects via calcium antagonism. The combination aims to provide synergistic relief from both pain and muscle spasm without significant sedative side effects[2][3][7][6].

Brand names
Pelubi (for pelubiprofen)pelubiprofen + eperisone
Other names
pelubiprofen/eperisoneeperisone/pelubiprofen
02

Targets

CaV (Voltage-gated calcium channel protein complex)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NaV (Voltage-gated sodium channels)PGHS-1 (Prostaglandin G/H Synthase 1)

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