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pembrolizumab + MKC1106-PP
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous, Intranodal
01
Overview
MKC1106-PP is an experimental "prime-boost" cancer immunotherapy developed by MannKind Corporation, consisting of a DNA plasmid (pSEM) for priming and a synthetic peptide mixture for boosting. It is designed to target five tumor-associated antigens: PRAME, PSMA, SSX2, NY-ESO-1, and Melan-A (MART-1). The therapy is typically administered via ultrasound-guided intranodal injection. While the provided name "Keytruda-Mannkind Corporation-solid tumor" suggests a combination with the PD-1 checkpoint inhibitor pembrolizumab (Keytruda), the specific trial context (NCT00435552) describes a Phase I study of MKC1106-PP as a monotherapy in patients with advanced, refractory solid malignancies. The combination of a DNA/peptide vaccine with a checkpoint inhibitor is a recognized therapeutic strategy to enhance T-cell responses, although this specific pairing was not the subject of the referenced MannKind trial.
- Other names
- pSEM + peptides
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)NY-ESO-1 (New york esophageal squamous cell carcinoma 1)MLANA (Melanoma antigen recognized by T cells 1)PRAME (Preferentially expressed antigen in melanoma)PSMA (Prostate-specific membrane antigen)SSX2 (Synovial sarcoma X breakpoint protein 2)
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