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pembrolizumab + vemurafenib
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination involves **pembrolizumab**, a monoclonal antibody that acts as a checkpoint inhibitor by blocking the PD-1 receptor, enhancing the immune response against cancer cells[6]. **Vemurafenib** is a BRAF inhibitor used in the treatment of melanoma with the BRAF V600E mutation, targeting the MAPK signaling pathway[8]. The combination aims to synergize immunotherapy with targeted therapy to improve outcomes in advanced melanoma.
02
Targets
AHR (Aryl hydrocarbon receptor)BRAF V600EPDCD1 (Programmed cell death protein 1 receptor)
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