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pemetrexed + pucotenlimab
- Development stage
- Preclinical
- Lead developer
- Eli Lilly
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A combination therapy consisting of pemetrexed, an antifolate agent that inhibits enzymes involved in purine and pyrimidine synthesis, and pucotenlimab, a humanized IgG4 monoclonal antibody targeting PD-1. This combination potentially combines cytotoxic effects with immunotherapy for cancer treatment.
02
Targets
DHFR (Dihydrofolate reductase)GART (GAR transformylase)TS (Thymidylate synthase)PDCD1 (Programmed cell death protein 1 receptor)
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