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pemigatinib + retifanlimab
- Development stage
- Phase 2
- Lead developer
- Incyte
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
A combination of two targeted anticancer agents: **pemigatinib**, a selective small molecule inhibitor of fibroblast growth factor receptor (FGFR) 1, 2, and 3, and **retifanlimab**, a monoclonal antibody that blocks programmed cell death protein 1 (PD-1). This combination is being investigated in clinical trials for the treatment of advanced or metastatic solid tumors, including dedifferentiated liposarcoma and other malignancies. The rationale is to combine FGFR inhibition, which blocks a pathway often dysregulated in cancers, with immune checkpoint inhibition, which enhances antitumor immune responses[1][2][4][7].
- Other names
- pemigatinib + retifanlimab
02
Targets
FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)PDCD1 (Programmed cell death protein 1 receptor)
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