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Pendulum Glucose Control
- Development stage
- Phase 2
- Lead developer
- Pendulum Therapeutics
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Pendulum Glucose Control is a multi-strain probiotic supplement developed by Pendulum Therapeutics, containing a proprietary blend of five live bacterial strains—*Akkermansia muciniphila*, *Clostridium butyricum*, *Clostridium beijerinckii*, *Anaerobutyricum hallii*, and *Bifidobacterium infantis*—along with the prebiotic chicory inulin. Originally designed and marketed for the management of type 2 diabetes to improve glucose control and A1C levels, the formulation is currently being evaluated in a Phase 1 clinical trial at the University of Cincinnati for its potential to mitigate radiation-induced gastrointestinal (GI) toxicity in patients receiving pelvic radiotherapy. The therapeutic rationale is based on the ability of these specific strains to restore gut microbiome homeostasis and strengthen the intestinal barrier; notably, *A. muciniphila* is thought to promote mucus layer maintenance and epithelial repair, thereby reducing the severity of GI symptoms associated with radiation-induced injury.
- Brand names
- Pendulum Glucose Control
- Other names
- PGC
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