penicillinase

Penicillinase is a recombinant enzyme belonging to the beta-lactamase family, specifically designed to catalyze the hydrolysis of the beta-lactam ring in penicillin-type antibiotics. This enzymatic action effectively neutralizes the antibacterial properties of the drug. Produced by Zhuhai Gene-Biocon, it is marketed as a recombinant enzyme and active pharmaceutical ingredient (API) for use by other pharmaceutical and cosmetic manufacturers. While historically used as a therapeutic agent to treat severe penicillin-induced allergic reactions (anaphylaxis) by rapidly clearing the antibiotic from the systemic circulation, its contemporary application is primarily focused on laboratory diagnostics, microbiology testing, and as a reagent in pharmaceutical manufacturing processes.

Other names

beta-lactamasepenicillin amido-beta-lactamhydrolasepenicillinase Ibeta-lactamase I