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Penn Microbiome Therapy
- Development stage
- Unknown
- Lead developer
- University of Pennsylvania
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Cell Therapies, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral, Rectal
01
Overview
Penn Microbiome Therapy (PMT) is a specific fecal microbiota transplant (FMT) intervention developed and produced by the University of Pennsylvania. It involves the transfer of a diverse, healthy microbial community from screened donors to a recipient's gastrointestinal tract to restore microbial balance and diversity. The therapy is primarily investigated as a treatment for severe or recurrent *Clostridium difficile* infections (CDI) and as a strategy for the decolonization of multidrug-resistant organisms (MDRO). By reintroducing a complex population of commensal bacteria, PMT aims to outcompete pathogens through competitive exclusion and restore the intestinal environment to a state that prevents the overgrowth of antibiotic-resistant or pathogenic bacteria.
- Other names
- Fecal Microbiota TransplantFMT
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