Drug intelligence / Profile preview

PentaLyte

Development stage
Preclinical
Lead developer
Lineage Cell Therapeutics
Modality
Albumin → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
Administration
Intravenous
01

Overview

**PentaLyte** is BioTime's proprietary intravenous colloid plasma-volume expander consisting of 6% pentastarch in a balanced lactated electrolyte solution. The formulation contains hydroxyethyl starch as the principal oncotic volume-expanding component, with electrolytes, glucose, and lactate buffer. It was developed for treatment of hypovolemia, particularly where relatively faster elimination of the starch component is desired. In a rabbit aortic occlusion-reperfusion model, PentaLyte resuscitation reduced hepatoenteric reperfusion injury and associated lung injury relative to lactated Ringer's resuscitation. ([sec.gov](https://www.sec.gov/Archives/edgar/data/876343/000095013404020044/f04328exv99w1.htm))

Brand names
PentaLyte
Other names
6% pentastarch in lactated electrolyte injection

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