pentamidine

Pentamidine is an antimicrobial and antiprotozoal small molecule used primarily to treat and prevent Pneumocystis pneumonia (PCP), especially in immunocompromised patients such as those with HIV/AIDS. It is also effective against other protozoal infections including African trypanosomiasis (sleeping sickness), leishmaniasis, babesiosis, and Balamuthia infections. The precise mechanism of action is not fully understood but involves interference with nuclear metabolism in susceptible organisms—specifically inhibiting the synthesis of DNA, RNA, phospholipids, and proteins. Pentamidine can be administered via inhalation or injection[1][2][3][6].

Brand names

NebupentPentamPentam 300Pentam300Pentam-300

Other names

pentamidinumpentamidinapentamidin1,5-bis(4-amidinophenoxy)pentane4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide4,4'-(pentamethylenedioxy)dibenzamidinep,p'-(pentamethylenedioxy)dibenzamidine