Drug intelligence / Profile preview

Pentarlandir UPPTA

Development stage
Phase 2
Lead developer
SyneuRx International
Modality
Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**Pentarlandir UPPTA** is an investigational, ultrapure and potent formulation of tannic acids developed using proprietary extraction technology, yielding a unique composition of galloyl polyphenols centered on a glucose moiety[2][1]. It demonstrates broad-spectrum antiviral activity, notably against SARS-CoV-2 and HCoV-OC43, by inhibiting viral replication and entry through dual targeting of the main coronavirus protease (**3-chymotrypsin-like protease, 3CLpro**) and the host cell serine protease (**TMPRSS2**) needed for viral entry into human cells[2][1][3]. Pharmacokinetic profiling indicates high distribution to lung tissue, no bodily accumulation, and a favorable safety/toxicity profile in preclinical studies[1][2]. Currently, it is in phase II clinical development for COVID-19 in mildly infected patients[3].

Brand names
Pentarlandir
Other names
ultrapure and potent tannic acidsUPPTAPentarlandir ultrapure and potent tannic acid
02

Targets

Mpro (3C-like proteinase of SARS-CoV-2)TMPRSS2 (Transmembrane protease serine 2)

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