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pentasodium tetracarboxymethyl palmitoyl dipeptide-12
- Development stage
- Unknown
- Lead developer
- Incospharm
- Modality
- Peptides
- Administration
- Topical
01
Overview
Pentasodium tetracarboxymethyl palmitoyl dipeptide-12 (PTPD-12) is a synthetic peptide developed by NeoPharm for the treatment of inflammatory skin conditions, specifically atopic dermatitis. It functions as an autophagy stimulator, a mechanism that enhances cellular degradation processes to manage inflammation and promote the restoration of the skin barrier. In clinical trials for mild-to-moderate atopic dermatitis, topical moisturizers containing PTPD-12 have demonstrated significant improvements in skin hydration, trans-epidermal water loss (TEWL), pruritus, and the SCORing Atopic Dermatitis (SCORAD) index score compared to baseline. The compound is designed to address the underlying barrier dysfunction and inflammatory pathways associated with atopic dermatitis.
- Brand names
- MelaTrepein
- Other names
- pentasodium tetracarboxymethyl palmitoyl dipeptide-12
02
Targets
PAR2 (Protease-activated receptor 2)
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