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peplomycin
- Development stage
- Unknown
- Lead developer
- Kyowa Kirin
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Antimicrobial Peptides → Native Peptides → Peptides, Cyclic Peptides → Modified Peptides → Peptides
- Administration
- Intravenous, Intramuscular, Intralesional
01
Overview
Peplomycin is a semisynthetic glycopeptide antineoplastic antibiotic, structurally related to bleomycin and derived from _Streptomyces verticillus_. It forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals, causing single-stranded and double-stranded breaks in DNA. This mechanism leads to inhibition of DNA synthesis and cell death. Peplomycin has demonstrated greater antitumor activity than bleomycin but its clinical use is limited by pulmonary toxicity. It is primarily indicated for the treatment of malignant lymphoma, head and neck cancer, lung cancer, prostate cancer, and skin cancer[1][2][3][4][7].
- Brand names
- Pepleo
- Other names
- peplomycin sulfate
02
Targets
DNA
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