Peptide Alarm Therapy

Peptide Alarm Therapy (PAT) is a novel immunotherapy approach designed to overcome the immunosuppressive tumor microenvironment in cancer. It involves the direct injection of viral peptides—specifically, peptides derived from Epstein-Barr virus and cytomegalovirus—into tumors. These viral peptides activate pre-existing, virus-specific CD8+ T memory cells that reside within or near tumors. Upon recognition of their cognate antigen, these T cells rapidly produce pro-inflammatory cytokines and chemokines, triggering a local immune response that recruits both innate and adaptive immune effectors to the tumor site. This "alarm" effect can enhance anti-tumor immunity even in cancers resistant to checkpoint blockade therapies. Preclinical studies have demonstrated efficacy in melanoma models, and clinical trials are ongoing for treatment-resistant glioblastoma multiforme[1][2].

Other names

PAT