PeptiSleep

PeptiSleep is a natural, plant-derived bioactive peptide ingredient developed by Nuritas using an AI-driven discovery platform[3][5][7][8]. It is sourced from rice bran protein and specifically designed to support all phases of sleep, enhancing both the quantity and quality of sleep—including deep and REM stages—without causing sedation or morning grogginess[3][5][7]. Mechanistically, PeptiSleep acts by modulating cortisol (helping to reduce stress-related hyperarousal) and downregulating the orexin (hypocretin) pathway, which calms the central nervous system and facilitates natural sleep onset and maintenance[1][8]. Clinically, PeptiSleep has demonstrated statistically significant improvements in measures such as sleep duration, sleep onset latency, sleep quality, and heart rate variability, supporting its role in promoting restorative sleep and balanced circadian rhythm[3][5][6][7]. It is a melatonin-free alternative, formulated for both dietary supplement and functional food applications, and can be found in numerous consumer products[4].

Brand names

PeptiSleep

Other names

PeptiSleep