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Perceptiv

Development stage
Unknown
Lead developer
University of Massachusetts Lowell
Modality
Small Molecules
01

Overview

Perceptiv (also known by its research code NF-02) is a multi-ingredient nutritional supplement formulation developed to support brain health and cognitive function, specifically in the context of Alzheimer's disease and age-related cognitive decline. Developed through research supported by the National Institute on Aging (NIA) and the University of Massachusetts Lowell, the formulation consists of a synergistic blend of six key nutrients: folic acid, vitamin B12, alpha-tocopherol (Vitamin E), S-adenosylmethionine (SAMe), N-acetyl cysteine (NAC), and acetyl-L-carnitine (ALCAR). The supplement is designed to address multiple neurodegenerative pathways by reducing oxidative stress, lowering homocysteine levels, maintaining healthy methylation cycles, and supporting mitochondrial energy production and neurotransmitter synthesis. Clinical evaluation in Phase 2 trials has demonstrated its potential to improve or stabilize cognitive performance and mood in patients with Alzheimer's disease.

Brand names
Perceptiv
Other names
Nutritional Brain Metabolic EnhancerNutritional SupplementShea Formulation
02

Targets

MTR (Methionine synthase)DNMT (DNA methyltransferase)CRAT (Carnitine O-acetyltransferase)

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