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Drug intelligence / Profile preview
peretinoin
- Development stage
- Phase 3
- Lead developer
- Kowa
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Peretinoin is an orally available small molecule classified as an acyclic retinoid. It acts primarily by binding to and activating nuclear retinoic acid receptor (RAR) and retinoid X receptor (RXR), which leads to the recruitment of coactivator proteins and the promotion of transcription of target genes involved in cell differentiation and apoptosis[1][2][5]. Peretinoin has demonstrated potential antineoplastic and chemopreventive activities. It is being developed mainly for the prevention of recurrence in hepatocellular carcinoma (HCC) after curative therapy[5]. Additional research suggests it may suppress hepatitis B virus replication by modulating sphingosine metabolic pathways and enhance autophagy via increased Atg16L1 expression[6][8].
- Brand names
- peretinoin
- Other names
- acyclic retinoid(2E,4E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,4,6,10,14-pentaenoic acid
02
Targets
RAR (Retinoic acid receptor)RXRA (Retinoid X receptor alpha)
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