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Perflutren lipid microspheres (Thomas Jefferson University)
- Development stage
- Unknown
- Lead developer
- Lantheus
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Perflutren lipid microspheres, marketed under the brand name Definity, is an ultrasound contrast agent consisting of octafluoropropane (perflutren) gas encapsulated within a lipid shell. The lipid shell is composed of dipalmitoylphosphatidylcholine (DPPC), methylpoly(ethylene glycol) dipalmitoylphosphatidylethanolamine (MPEG5000 DPPE), and dipalmitoylphosphatidic acid (DPPA). While it is FDA-approved for use in echocardiography to opacify the left ventricular chamber and improve the delineation of the endocardial border, it is being investigated by Thomas Jefferson University in an early phase 1 clinical trial for patients with breast cancer. In this investigational setting, contrast-enhanced ultrasound (CEUS) using these microspheres is employed to noninvasively estimate interstitial fluid pressure (IFP) by analyzing subharmonic signals, which may provide critical insights into the tumor microenvironment and treatment response.
- Brand names
- Definity
- Other names
- Perflutren lipid-type A microspheresOctafluoropropane lipid microspheres
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