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Pergabaiox
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Pergabaiox is an oral small molecule medication containing pregabalin, developed and marketed by the Iranian pharmaceutical company Bakhtar Bioshimi. It functions by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces the calcium-dependent release of several neurotransmitters, including glutamate, norepinephrine, and substance P. This mechanism provides analgesic, anticonvulsant, and anxiolytic effects. Pergabaiox is indicated for the treatment of neuropathic pain (such as diabetic peripheral neuropathy and postherpetic neuralgia), as adjunctive therapy for partial-onset seizures in patients with epilepsy, and for the management of generalized anxiety disorder.
- Brand names
- Pergabaiox
- Other names
- پرگابایوکسpregabalin
02
Targets
CACNA2D2 (α2δ-2)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)
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