Drug intelligence / Profile preview

Pericapsular Nerve Group block

Development stage
Unknown
Lead developer
Bursa City Hospital
Modality
Small Molecules
Administration
Perineural Injection
01

Overview

The Pericapsular Nerve Group (PENG) block is a regional anesthesia technique primarily used for postoperative pain management in hip and knee surgeries. In the clinical trial context provided by Bursa City Hospital, the PENG block involves the ultrasound-guided administration of a local anesthetic, specifically 30 ml of 0.25% bupivacaine (Marcain), into the fascial plane between the psoas tendon and the superior pubic ramus. This technique targets the articular branches of the femoral, obturator, and accessory obturator nerves to provide effective analgesia while potentially sparing motor function. Bupivacaine, the active pharmaceutical agent, acts by blocking voltage-gated sodium channels, thereby inhibiting the initiation and conduction of pain signals from the surgical site.

Brand names
Marcain
Other names
PENG blockPENG block-Bursa City Hospital-postoperative pain
02

Targets

NaV (Voltage-gated sodium channels)

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