Drug intelligence / Profile preview

perilla fruit

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral (as Decoction/tea), Oral (granules/powder), Oral (tincture/liquid Extract)
01

Overview

Perilla fruit refers to the dried ripe fruit (seed) of *Perilla frutescens*, a plant widely used in Traditional Chinese Medicine (TCM) and East Asian herbal practices. In TCM, perilla fruit (Zi Su Zi) is categorized as a warm herb that transforms phlegm and stops cough. It is primarily used to direct rebellious Lung Qi downward, arrest wheezing and coughing due to cold-phlegm accumulation in the lungs, expel phlegm by moistening the lungs and intestines, and lubricate the bowels for constipation relief. The main active constituents include phenolic compounds with antioxidant properties[5][7]. Modern research suggests potential anti-inflammatory and antiallergic effects; however clinical evidence for specific indications remains limited[2][8]. The seeds are also rich in dietary fiber and minerals such as calcium and iron[7].

Other names
Zi Su Zi紫苏子Fructus PerillaePerilla seedsPerillae Fructus PraeparataKorean perillaJapanese sweet basilShiso
02

Targets

CYP2A6 (Cytochrome P450 2A6)CYP3A4 (Cytochrome P450 3A4)OLR1 (Lectin-like oxidized LDL receptor-1)CYP2B6 (Cytochrome P450 2B6)

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