perilla frutescens extract

Output based on the provided text, not requiring specific reformatting beyond what's specified for JSON. **Perilla frutescens extract** is a natural plant-derived extract obtained from the leaves, seeds, or other parts of *Perilla frutescens* (a member of the mint family widely used in traditional East Asian medicine and cuisine)[1][3][5]. Its principal bioactive compounds include flavonoids (such as apigenin, luteolin, scutellarein derivatives), rosmarinic acid, polyphenols, and essential oils[1][2][3]. The extract exhibits a variety of pharmacological activities, including anti-inflammatory, antioxidant, anti-allergic, neuroprotective, anticancer, antimicrobial, antidepressant, and hepatoprotective effects[1][3][5]. Mechanistically, these effects are attributed mainly to inhibition of pro-inflammatory cytokines, suppression of reactive oxygen species (ROS) generation, inhibition of enzymes such as hyaluronidase, aldose reductase, α-glucosidase, xanthine oxidase, and tyrosinase, and blockade of JNK/ERK pathways (notably by compounds like rosmarinic acid)[1][3]. The extract has been primarily researched for its use in allergic rhinitis, with additional explored uses in depression, rheumatoid arthritis, cholesterol control, diabetes complications, certain cancers, and neurodegenerative disorders[1][3][5]. Most evidence comes from preclinical and animal models, though some human studies indicate benefit for seasonal allergies[3][5].

Other names

Perilla extractPerilla leaf extractPerilla herb extractPerilla seed extractPerillae folium extract