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perilla leaf extract
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Perilla leaf extract (PLE) is a botanical extract derived from *Perilla frutescens* (L.) Britt., a traditional medicinal plant known for its antioxidant and anti-inflammatory properties. PLE has been studied for its potential to treat respiratory diseases, specifically chronic obstructive pulmonary disease (COPD). Its therapeutic effect is attributed to the suppression of the TLR4/Syk/PKC/NF-κB p65 signaling pathway, which results in reduced infiltration of inflammatory cells like neutrophils and macrophages into lung tissue. Additionally, PLE inhibits the production of key inflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-17A (IL-17A), thereby ameliorating airway inflammation.
- Other names
- Perilla frutescens leaf extract
02
Targets
SYK (Spleen Tyrosine Kinase)PRKCI (Protein kinase C iota)RELA (Nuclear Factor Kappa B Subunit p65)TLR4 (Toll-like receptor 4)
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