perillic acid

**Perillic acid** is a naturally occurring monoterpenoid carboxylic acid, classified as a menthane monoterpenoid, most commonly found as a metabolite of limonene in humans and some plants such as *Perilla frutescens* and *Citrus* species[1][5][7]. It is a highly hydrophobic, practically water-insoluble solid. Perillic acid displays reported **antimicrobial** and **anticancer** activity, with suggested mechanisms partly via interference with posttranslational cysteine isoprenylation affecting small G proteins (such as p21ras), resulting in induction of apoptosis by upregulation of p21, Bax, and caspase-3[2][8]. It has been studied as an antineoplastic agent and is a known biomarker in metabolism studies, and is also suggested as a possible biomarker for Parkinson’s disease[2][8].

Other names

perillic acid(-)-perillic acidperillate(S)-(-)-perillic acid4-(prop-1-en-2-yl)cyclohex-1-ene-1-carboxylic acid4-isopropenylcyclohex-1-enecarboxylic acidp-mentha-1,8-dien-7-oic acid(S)-4-Isopropenylcyclohexene-1-carboxylic acid(4S)-4-(prop-1-en-2-yl)cyclohex-1-ene-1-carboxylic acid(S)-4-(1-methylethenyl)-1-cyclohexene-1-carboxylic acid1-cyclohexene-1-carboxylic acid 4-(1-methylethenyl)