perindopril erbumine + indapamide

Perindopril erbumine + indapamide is a fixed-dose combination (FDC) medication used for the management of essential hypertension. It combines perindopril erbumine, a long-acting angiotensin-converting enzyme (ACE) inhibitor, with indapamide, a thiazide-like diuretic. Perindopril acts as a prodrug for perindoprilat, which inhibits ACE, thereby reducing the production of angiotensin II, decreasing aldosterone secretion, and increasing levels of the vasodilator bradykinin. Indapamide exerts its diuretic effect by inhibiting sodium reabsorption in the distal convoluted tubule of the kidney. The combination provides a synergistic antihypertensive effect, often used when blood pressure is not adequately controlled by monotherapy. It is available in several dose strengths and is marketed globally under various brand names.

Brand names

PreteraxBi-PreteraxNoliprelSandoz Perindopril Erbumine/IndapamideCoversyl Plus

Other names

Perindopril tert-butylamine + indapamide