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PERIPATEI
- Development stage
- Unknown
- Lead developer
- Centre Hospitalier Universitaire de Clermont-Ferrand
- Modality
- Small Molecules
01
Overview
PERIPATEI is a multimodal rehabilitation walking program developed by University Hospital, Clermont-Ferrand, for patients with painful hip or knee osteoarthritis. The program involves the transient, tailored administration of non-steroidal anti-inflammatory drugs (NSAIDs)—specifically niflumic acid, diclofenac, ketoprofen, or ibuprofen—combined with acetaminophen. The choice of NSAID is determined by the patient's cardiovascular and gastrointestinal risk profiles. This pharmacological regimen is integrated with a structured walking program, physical techniques such as appropriate footwear, and patient education aimed at reducing fear-avoidance behaviors. The trial evaluates the efficacy and tolerance of this intermittent drug intake strategy to improve mobility and walking ability while minimizing the adverse effects associated with chronic NSAID use.
- Other names
- nsaid-University Hospital, Clermont-Ferrand-osteoarthritisRehabilitation Walking Program with Transient NSAID for Hip/Knee Osteoarthritis
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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