periplaneta americana aqueous extract

Periplaneta americana aqueous extract is a water-based extract derived from the American cockroach, an insect that has been utilized in traditional Chinese medicine for centuries. [14] The extract is a complex mixture containing multiple bioactive components, including amino acids, peptides, nucleosides, and other compounds. [5, 19] It demonstrates significant tissue-repairing, anti-inflammatory, and immunomodulatory properties. [5, 11] Its mechanism of action is multifactorial, involving the activation of the JAK/STAT3 signaling pathway to promote cell proliferation and migration for wound healing, modulation of inflammatory mediators through the TLR4/MyD88/NF-κB pathway, and regulation of the gut microbiota. [1, 2, 5] The extract is being clinically used and investigated for various conditions, most notably ulcerative colitis and the healing of cutaneous wounds, burns, and ulcers. [3, 5, 7]

Other names

American cockroach aqueous extract