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periploca forrestii n-butanol fraction
- Development stage
- Preclinical
- Lead developer
- Guilin Medical University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
The n-butanol fraction of *Periploca forrestii* Schltr. ethanol extract is a research-stage natural product mixture derived from the traditional Chinese medicinal plant *Periploca forrestii*. It is being investigated primarily by researchers at Guilin Medical University for its potential in treating Alzheimer's disease and arthritis. The fraction is composed of seventeen identified active components, including phenylpropanoids, flavonoids, anthraquinones, triterpenoids, and steroids. Network pharmacology and molecular docking studies suggest that the extract interacts with multiple biological targets, such as Tumor Necrosis Factor (TNF), AKT Serine/Threonine Kinase 1 (AKT1), and Estrogen Receptor 1 (ESR1), to exert anti-inflammatory and neuroprotective effects.
- Other names
- n-butanol fraction of Periploca forrestii Schltr. ethanol extractn-butanol extract of Periploca forrestiiPeriploca forrestii n-butanol extract
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ESR1 (ERα)
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