PERK antisense morpholino

PERK antisense morpholino is a synthetic oligonucleotide designed to knockdown the expression of PKR-like endoplasmic reticulum kinase (PERK), a key sensor in the unfolded protein response (UPR) pathway. In the context of cancer immunotherapy, PERK inhibition in T-cells has been shown to modulate metabolism, increasing glycolysis and mitochondrial bioenergetics, which restores cytolytic function and enhances responsiveness to PD-1 checkpoint inhibitors. Unlike small molecule PERK inhibitors like GSK2606414, which can cause pancreatic beta-islet damage and insulin resistance, the antisense morpholino approach has demonstrated reduced off-target toxicity in preclinical melanoma models. This agent is primarily used as a research tool to investigate the role of ER stress in the tumor microenvironment and its impact on T-cell effector function.

Other names

antisense morpholino targeting PERKPERK morpholino