Drug intelligence / Profile preview

permethrin

Development stage
Approved
Modality
Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Permethrin is a synthetic pyrethroid insecticide and topical anti-parasitic medication used primarily to treat scabies and head lice in adults and children. It is available as a cream or lotion for topical application. Permethrin acts by disrupting sodium channel currents on the nerve cell membranes of arthropods (such as mites and lice), leading to delayed repolarization, paralysis, and death of the parasites. Its absorption through human skin is minimal; it is rapidly metabolized mainly in the liver via ester hydrolysis and excreted primarily in urine. Permethrin is also widely used as an insecticide for clothing or mosquito nets[1][2][3][4][5].

Brand names
ActicinElimiteNixLice Bedding SprayNix Complete Lice TreatmentNix Complete Lice Treatment SystemNix Cream Rinse
Other names
permethrinum
02

Targets

NaV alpha (Voltage-gated sodium channel alpha subunit family)PXR (Pregnane X receptor)ER (Estrogen receptor)

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