Drug intelligence / Profile preview

Persea americana leaf phenolic extract

Development stage
Preclinical
Administration
Oral
01

Overview

Persea americana leaf phenolic extract is a botanical preparation derived from the leaves of the avocado tree (*Persea americana*). It contains a complex profile of bioactive phenolic compounds, including syringic acid, kaempferol, catechin, and epigallocatechin-3-O-gallate. The extract is primarily studied for its anti-diabetic potential, which is mediated through the inhibition of key carbohydrate-metabolizing enzymes, specifically alpha-amylase and alpha-glucosidase. By inhibiting these enzymes, the extract helps to slow the digestion of dietary carbohydrates and reduce postprandial blood glucose levels. Additionally, the extract exhibits significant antioxidant properties, as evidenced by its ability to inhibit lipid peroxidation and reduce malondialdehyde (MDA) levels in pancreatic tissues, potentially protecting against oxidative stress-induced damage associated with type 2 diabetes.

Other names
avocado leaf phenolic extractPersea americana leaf extract
02

Targets

Sucrase-IsomaltaseAMY (Pancreatic alpha-amylase)

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