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perseris
- Development stage
- Approved
- Lead developer
- Indivior
- Modality
- Small Molecules, Drug Delivery Systems
- Administration
- Subcutaneous
01
Overview
Perseris is a long-acting, once-monthly subcutaneous injectable formulation of risperidone, an atypical antipsychotic. It is indicated for the treatment of schizophrenia in adults. The drug delivers risperidone in an extended-release system using a poly (DL-lactide-co-glycolide) polymer matrix, allowing for steady medication levels throughout the month without the need for oral supplementation or loading doses. Risperidone acts primarily as an antagonist at dopamine D2 and serotonin 5-HT2A receptors, helping to balance neurotransmitters involved in mood and thought regulation. Perseris was developed to improve adherence by reducing dosing frequency compared to daily oral formulations[1][2][3][5][9].
- Brand names
- Perseris
- Other names
- risperidone extended-release injectable suspension
02
Targets
ADRA1A (α1A)ADRA2A (α2A)DRD2 (Dopamine D2 Receptor)HRH1 (Histamine H1 Receptor)HTR2A (Serotonin receptor 5-HT2A)
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