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Persumac is an Iranian traditional medicine remedy composed of Sumac (*Rhus coriaria*) and *Bunium persicum* (Black Cumin). It is developed by the Mashhad University of Medical Sciences and is primarily investigated for the management of refractory chemotherapy-induced nausea and vomiting (CINV) in patients with breast cancer. The combination is hypothesized to reduce the frequency and severity of nausea and vomiting in both acute and delayed phases following chemotherapy. As a botanical product, it contains a complex mixture of phytochemicals that may exert anti-emetic effects through gastroprotective and potentially neuroprotective pathways.
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