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PEV2B

Development stage
Phase 1
Lead developer
Pevion Biotech
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

PEV2B is a virosome-based vaccine candidate developed by Pevion Biotech for the treatment or prevention of Hepatitis C Virus (HCV) infection. It utilizes a proprietary virosome delivery platform, which consists of synthetic lipid bilayers containing influenza virus surface glycoproteins (hemagglutinin and neuraminidase) but lacking the viral genome. These virosomes serve as both a delivery vehicle and a potent adjuvant. PEV2B specifically carries antigens derived from the HCV envelope glycoproteins E1 and E2. In Phase I clinical trials, it was administered alongside PEV2A (which contains HCV core protein antigens) to evaluate safety and the induction of specific humoral and cellular immune responses against HCV.

Other names
HCV virosome vaccine component PEV2B
02

Targets

HCV E2 (Hepatitis C virus envelope glycoprotein E2)HCV E1 (Hepatitis C virus envelope glycoprotein E1)

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