PF-00356231

PF-00356231 is an experimental small molecule inhibitor of matrix metalloproteinase 12 (MMP‑12). It is a non-peptidic, non-zinc chelating ligand that selectively inhibits MMP‑12 with an IC50 of approximately 1.4 μM. At higher concentrations, it may also inhibit other matrix metalloproteinases. The compound belongs to the phenylpyridine class and was developed as a potential therapeutic for conditions involving MMP‑12 activity, such as inflammatory or degenerative diseases[1][2][3][9]. Its chemical formula is C25H20N2O3S and its CAS number is 766536‑21‑4[1].

Other names

(3R)-3-Phenyl-3-[({4-[4-(4-pyridinyl)phenyl]-2-thienyl}carbonyl)amino]propanoic acid3-phenyl-3-({[4-(4-pyridin-4-ylphenyl)thien-2-yl]carbonyl}amino)propanoic acid