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PF-00885706

Development stage: Discontinued
Lead developer: Pfizer
Modality: Small Molecules
Administration: Oral

Overview

PF-00885706 is a small molecule 5-HT4 receptor partial agonist that was developed by Pfizer for the treatment of gastro-esophageal reflux disease (GERD). It was specifically evaluated as an adjunctive treatment for patients who experienced persistent symptoms despite standard proton pump inhibitor (PPI) therapy. By targeting the 5-HT4 receptor, the compound aims to promote gastric emptying and increase lower esophageal sphincter pressure, thereby reducing reflux episodes. Although it reached Phase 2 clinical trials, development was ultimately discontinued.

Targets

HTR4 (5-Hydroxytryptamine receptor 4)

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