PF-05105679

PF-05105679 is a potent and selective small molecule antagonist of the Transient receptor potential cation channel subfamily M member 8 (TRPM8) ion channel, which is the primary receptor responsible for the sensation of cold. Developed by Pfizer as a potential analgesic, it blocks cold sensation in both animal models and human trials. While it lowers core body temperature in small mammals, this effect was not observed in humans at pharmacologically relevant doses. The drug has been evaluated primarily for its ability to treat cold-induced pain sensitivity (cold allodynia), with clinical studies showing efficacy in reversing cold pain without affecting core body temperature regulation[1][4][5][6].

Other names

1398583-31-7F2B10OFV7YF-2B10OFV7YF 2B10OFV7Y