PF-06380101

PF-06380101 is a **novel cytotoxic Dolastatin 10 analogue** that functions as a microtubule inhibitor[1][7][9]. It is a **small molecule** with potent anti-proliferative effects, primarily used as a payload component for antibody-drug conjugates (ADCs), offering excellent activity in tumor cell proliferation assays and differential ADME (absorption, distribution, metabolism, and excretion) properties when compared to other synthetic auristatin analogues[1][7][9]. PF-06380101 is intended for research use and is not approved for clinical use. Its mechanism of action involves disrupting microtubule dynamics, leading to mitotic arrest and apoptosis in neoplastic (cancer) cells[1][5][7][9]. The developer and main active organization is Pfizer[5].

Brand names

Aur0101Aur-0101Aur 0101

Other names

PF-06380101PF06380101PF 06380101Aur0101Aur-0101Aur 0101Dolastatin 10 analogueDolastatin10 analogueDolastatin-10 analogue