PF-06663872

PF-06663872 is a pharmacologically active **metabolite** of PF-06412562, an orally bioavailable, selective partial agonist of the D1 and D5 dopamine receptors. PF-06663872 exhibits similar pharmacological activity to PF-06412562, contributing to central D1 receptor activation in the brain. Its exposure in plasma is lower than the parent drug and increases proportionally with dose. PF-06663872 has been studied in the context of cognitive impairment and motivational deficits, particularly in neuropsychiatric and neurodegenerative disorders such as Parkinson's disease as part of PF-06412562 metabolic studies[1][3][5].