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PF-07038124
- Development stage
- Phase 2
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
PF-07038124 is a topical, investigational small molecule drug developed by Pfizer for the treatment of atopic dermatitis (AD) and plaque psoriasis. It is a potent, oxaborole-based phosphodiesterase 4 (PDE4) inhibitor with immunomodulatory activity in T-cell–based assays, contributing to the inhibition of cytokines such as IL-4 and IL-13. The drug is designed to be applied as an ointment directly to affected skin areas and utilizes a "soft-drug" approach—being rapidly inactivated upon entering systemic circulation, which may reduce systemic side effects. Clinical trials have shown that PF-07038124 can improve symptoms in patients with mild to moderate AD or plaque psoriasis, though some studies found differences versus placebo were not always statistically significant[1][3][5][6][7].
- Other names
- CAS 2415085-44-6CAS2415085-44-6CAS-2415085-44-6
02
Targets
PDE4B (3',5'-cyclic-AMP phosphodiesterase 4B)PDE4D (Phosphodiesterase 4D)
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